Growing clinical evidence indicates that dietary L-arginine supplementation can reduce obesity, decrease arterial blood pressure, resist oxidation and normalize endothelial dysfunction to cause remission of type 2 diabetes. The potential molecular mechanism plays a role in modulating glucose homeostasis, promoting lipolysis, maintaining hormone level, ameliorating insulin resistance, and fetal programing in early stage.

The possible signaling pathway of the beneficial effects of L-arginine likely involves L-arginine-nitric oxide pathway through which cell signal protein can be activated. Accumulating studies have indicated that L-arginine may have potential to prevent and/or relieve type 2 diabetes via restoring insulin sensitivity in-vivo.

l-Arginine: anti-aging pilot study

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