NITRIC OXIDE AND BONE

Author
Dr. Deborah M. Evans

Abstract
Nitric oxide (NO), a mediator of cardiovascular homeostasis, neurotransmission, and immune function, has recently been found to have important effects in bone. Both constitutive and inducible forms of NO synthase are expressed by bone-derived cells, and cytokines such as interleukin-1 (IL-1), tumor necrosis factor (TNF), and interferon gamma (IFN-γ), are potent stimulators of NO production. When combined with other cytokines, IFN-γ markedly induces NO production, which suppresses osteoclast formation and activity of mature osteoclasts.

NITRIC OXIDE AND BONE

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