THIS WEBSITE IS DESIGNED TO INFORM YOU ABOUT THE IMPORTANCE OF THE NITRIC OXIDE MOLECULE IN OUR VASCULAR SYSTEM.¹

In the year 1998, the Nobel Prize in Physiology or Medicine was awarded to three US scientists for the discovery of this nitric oxide as a signalling molecule (miracle molecule) in the cardiovascular system.

It is becoming increasingly clear how important it is for the body to make nitric oxide, and what goes wrong in patients or subjects who cannot make nitric oxide.

Through research, we are beginning to understand how therapeutically to solve the underlying problems of Nitric Oxide deficiency. 

Although nitric oxide is widely recognised and appreciated in the scientific and medical community, there is still little awareness of this molecule.

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WHY IS NITRIC OXIDE IMPORTANT?

The Nitric Oxide Society explains it as follows:¹⁰

Cardiovascular disease – nitric oxide is the most important molecules produced in our cardiovascular system. In fact, loss of the production of nitric oxide is recognized as one of the earliest events in the onset and progression of cardiovascular disease.

From high blood pressure, heart failure, coronary artery disease, atherosclerosis, heart attack and stroke, nitric oxide play an essential role in combatting all these conditions.

Cancer – nitric oxide appears to play a dual role in cancer. Low, physiological levels of NO appear to have anti-cancer properties whereas higher concentrations produced for prolonged periods may contribute to cancer cell growth and proliferation. 

There is much focus and current research on understanding how NO affects cancer cell growth.

Immune system responds by producing massive amounts of nitric oxide acutely to kill these pathogens. The production and regulation of nitric oxide by our immune system can help keep us free from any chronic infections.

Physical performance– your ability to generate nitric oxide may predict how well you perform athletically.

Nitric oxide not only controls and regulates blood flow to working skeletal and heart muscles, but also controls how efficiently your mitochondria generate cellular energy from oxygen. 

Exercise intolerance in older individuals is due to these people being unable to effectively produce nitric oxide and regulate blood flow to the body.

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Dr. Jonathan S. Stamler– Professor of Medicine at Duke University Medical Center: ²

"It does everything, everywhere. You cannot name a major cellular response or physiological effect in which, nitric oxide, is not implicated today.

It’s involved in complex behavioural changes in the brain, airway relaxation, beating of the heart, dilation of blood vessels, regulation of intestinal movement, function of blood cells, the immune system, even how fingers and arms move."

Dr. Louis J. Ignarro 1998 Nobel Laureate in Medicine and author of the book, NO More Heart Disease.³

Synopsis of his book: “Though NO’s structure is simple, nitric oxide is now regarded as the most significant molecule in the body, absolutely crucial to your well-being. 

I am convinced that nitric oxide can age-proof your cardiovascular system, keeping it much fitter than your chronological age would indicate. 

Repairing the damage wrought by cardiovascular disease without risky and often ineffective surgery had long been considered impossible.

I was awarded the Nobel Prize in Medicine for making that thinking obsolete. 

Now we know we can reverse cardiovascular impairment naturally – with the body’s internally manufactured ‘wonder drug,’ nitric oxide."

RECOVER-ME IS DEVELOPED ON THE BASIS OF THE  NOBEL PRIZE IN PHYSIOLOGY OR MEDICINE 1998,¹

awarded for the discovery concerning nitric oxide as a signalling molecule in the cardiovascular system, by a renowned professor emeritus of organic chemistry. The Recover-Me formula stimulates the production of this nitric oxide (gas) in your blood vessels.⁴

The formulation of Recover-Me has been kept as simple as possible to avoid counter effects that often occur whenever unrelated and incompatible ingredients are blend together. Focus has always been on positive impact rather than creating an “impressive” label with a long list of ingredients. 

After studying existing products on the market we deliberately choose to only use ingredients that are scientifically proven to work well together. Mixing ingredients that are not scientifically tested in a blended form exposes the consumer to unwanted side effects or no effect at all. (Even if these ingredients are individually proven to be safe or effective to various levels).

Recover-Me is based on a scientific study conducted according to scientific parameters by Dr. A. Isidori, in 1981 at the University of Rome. We have improved the formulation and made Recover-Me with ingredients of the highest quality.⁴

For these quality reasons, Recover-Me is made in Europe, in a laboratory that meets the strictest regulatory guidelines. We use only the highest available pharmaceutical grade ingredients for consistent quality and complete customer satisfaction.⁹

We use the right kind of L-Arginine, Pidolate, (the salt of L-Arginine) which in combination with L-Lysine the absorption of L-Arginine increases.⁵ L-Lysine and L-Arginine should not be taken together if the are of the *L* form, because L-Arginine⁶ and L-Lysine⁷ compete for the same receptors. However L-Arginine Pidolate attaches to a different receptor and allows a synergistic effect between the two. Isomaltulose ⁸ (has a low sugar content) is added so that it is slowly absorbed into the blood

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Nitric Oxide protects the heart, stimulates the brain, kills bacteria, etc. ¹

It was a sensation that this simple, common air pollutant, which is formed when nitrogen burns, for instance in automobile exhaust fumes, could exert important functions in the organism. 

It was particularly surprising since Nitric Oxide (NO) is totally different from any other known signal molecule and so unstable that it is converted to nitrate and nitrite within 10 seconds. Nitric Oxide was known to be produced in bacteria but this simple molecule was not expected to be important in higher animals such as mammals.

Further research results rapidly confirmed that Nitric Oxide (NO) is a signal molecule of key importance for the cardiovascular system and it was also found to exert a series of other functions. We know today that NO acts as:

• A signal molecule in the nervous system,
• As a weapon against infections,
• As a regulator of blood pressure
• As a gatekeeper of blood flow to different organs.

Nitrogen monoxide (NO) is present in most living things and made by many different types of cells.

1. When NO is produced by the innermost cell layer of the arteries, the endothelium, it rapidly spreads through the cell membranes to the underlying muscle cells. Their contraction is turned off by NO, resulting in a dilatation of the arteries. In this way, NO controls the blood pressure and its distribution. It also prevents the formation of thrombi.
2. When NO is formed in nerve cells, it spreads rapidly in all directions, activating all cells in the vicinity. This can modulate many functions, from behaviour to gastrointestinal motility.
3. When NO is produced in white blood cells (such as macrophages), huge quantities are achieved and become toxic to invading bacteria and parasites.

Importance in medicine today and tomorrow.¹

Heart: In atherosclerosis, the endothelium has a reduced capacity to produce NO. However, NO can be furnished by treatment with nitroglycerin. Large efforts in drug discovery are currently aimed at generating more powerful and selective cardiac drugs based on the new knowledge of NO as a signal molecule.

Shock: Bacterial infections can lead to sepsis and circulatory shock. In this situation, NO plays a harmful role. White blood cells react to bacterial products by releasing enormous amounts of NO that dilate the blood vessels. The blood pressure drops and the patient may become unconscious. In this situation, inhibitors of NO synthesis may be useful in intensive care treatment.

Lungs: Intensive care patients can be treated by inhalation of NO gas. This has provided good results and even saved lives. For instance, NO gas has been used to reduce dangerously high blood pressure in the lungs of infants. But the dosage is critical since the gas can be toxic at high concentrations..

Cancer: White blood cells use NO not only to kill infectious agents such as bacteria, fungi and parasites, but also to defend the host against tumours. Scientists are currently testing whether NO can be used to stop the growth of tumours since this gas can induce programmed cell death, apoptosis.

Impotence: NO can initiate erection of the penis by dilating the blood vessels to the erectile bodies. This knowledge has already led to the development of new drugs against impotence.

Diagnostic analyses: Inflammatory diseases can be revealed by analysing the production of NO from e.g. lungs and intestines. This is used for diagnosing asthma, colitis, and other diseases NO is important for the olfactory sense and our capacity to recognise different scents. It may even be important for our memory.

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